Samuel married Louisa Elizabeth Gaines on 04 Feb 1845 in Cherokee County, Geotgia. Louisa (daughter of Henry Strother Gaines and Rhoda E. Bates) was born about 1828 in Rabun County, Georgia. [Group Sheet] [Family Chart]

1. Henry C. Messer was born about 1846 in Cherokee County, Georgia.
2. Sarah Demetris Messer was born on 23 Feb 1849 in Cherokee County, Georgia; died on 12 Jun 1896 in Cherokee County, Georgia; was buried in Macadonia Cemetery, Cherokee County.
3. Thomas J. Messer was born on 18 Jul 1857 in Cherokee County, Georgia; died on 20 Oct 1891 in Cherokee County, Georgia; was buried in Macedonia, Cherokee County.
4. Elias M. Messer was born about 1862 in Cherokee County, Georgia.